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KMID : 0604520190450040363
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Journal of the Society of Cosmetic Scientists of Korea
2019 Volume.45 No. 4 p.363 ~ p.372
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Anti-Inflammatory and Moisturizing Effect of Centella Extracts Fermented in Jeju Lava Water
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Lee Jee-Sun
Myung Cheol-Hwan
Lee Ji-Eun
Jo Mi-Rae
Kim Hong-Suk
Lee Na-Young
Woo Hee-Dong
You Jae-Eun
Jo Hae
Hwang Jae-Sung
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Abstract
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The leaves and stems of Centella asiatica have a long history of their usage as a medicine for the treatment of skin diseases such as ulcers and psoriasis, especially in Asia. Triterpenoids, the active components of Centella asiatica including asiaticoside, madecasosside, asiatic acid and madecassic acid, have shown to inhibit skin inflammation as well as improve skin photoaging. The main objective of this study is to investigate whether the Centella asiatica ripened with lava seawater which is rich in minerals known to be beneficial to human body can provide anti-inflammatory and moisturizing effects to skin. HPLC analysis showed that the concentration of triterpenoids increased further after ripening Centella asiatica with lava seawater. In order to confirm the inflammatory efficacy of the extract of the extract of the ripened Centella asiatica, the production of NO in LPS-activated RAW 264.7 cells and the expression of inflammatory cytokines in PM10 or UVB-induced HaCaT cells were observed. We found that the extract of the ripened Centella asiatica inhibited the expression of NO, IL-6, IL-8, and TNF-a and had higher inhibitory effect compared to the extract of the non-ripened Centella asiatica. In order to confirm the skin moisturizing effect, we investigated the synthesis of HA in HaCaT cells. The result showed HA production was enhanced in a concentration-dependent manner from the ripened group, while there was no efficacy from the non-ripened group. Taken together, it is concluded that the extract of the Centella asiatica ripened with lava seawater was effective in anti-inflammation and moisturization.
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KEYWORD
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Centella asiatica, lava sea water fermentation, Centella extract, anti-inflammatory, moisturizing agent
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